NDST1

Across TCGA pan-cancer cohorts, NDST1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NDST1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NDST1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NDST1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where NDST1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.995	0.749	.002	20	view →
PDAC	OS	Median	II,III,IV	0.277	0.462	.009	18	view →
LSCC	OS	Quartile	II,III,IV	0.583	0.944	.003	13	view →
CCRCC	OS	Tertile	All	1.000	0.892	.042	3	view →
LUAD	OS	Median	All	0.988	0.947	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NDST1–HNSC (OS)

Open the HNSC breakdown →