kininogen 1Genealiases: BDK · BK · HAE6 · HK · HMWK · KNG
Q-omics provides the consensus-scored KNG1 profile across patient tissues and cancer cell-line models. KNG1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, KNG1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, KNG1 protein abundance shows 38,850 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight LIHC, KIRC, and PDAC as cancer lineages where KNG1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KNG1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KNG1 survival associations across molecular data types. KNG1 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (6) and mass-spec protein abundance (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KNG1 RNA expression–survival associations across cancer types. High KNG1 expression shows unfavorable associations in KIRP, LGG, CHOL and COAD, but favorable associations in LIHC and READ. The LIHC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for KNG1 RNA expression.
This table summarizes KNG1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 10. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for KNG1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KNG1 shows lower tumor expression in KIRC, KIRP, KICH, COAD and CHOL and higher tumor expression in STAD. The KIRC box plot shows higher KNG1 RNA expression in normal versus tumor tissue (log2 FC = −8.568, t-test p < 0.001).
This table shows molecular features associated with KNG1 in patient tissues and cancer cell lines. In patient samples, KNG1 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, KNG1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in KIDNEY and LARGE_INTESTINE.
