KNG1

Across TCGA cell cohorts, KNG1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KNG1-associated genes across cancer lineages are GUCA2A, DNAAF6, and C22orf31. Each is linked with KNG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KNG1-to-partner and partner-to-KNG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by KNG1-low versus KNG1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNG1→partner) and Y-score (partner→KNG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GUCA2A →	+0.540	+3.635	<.001	.007	3	2
BLOOD_Leukemia	DNAAF6 →	+0.031	+3.847	.001	.007	3	2
SOFT_TISSUE	C22orf31 →	+0.230	+3.678	.003	.009	3	1
SOFT_TISSUE	LRRC74A →	+0.015	+4.169	<.001	.002	3	1
SOFT_TISSUE	C1orf189 →	+0.164	+3.865	.001	.006	3	1
SOFT_TISSUE	CLCA4 →	+0.299	+3.865	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GUCA2A by KNG1 expression — SOFT_TISSUE

Explore this box plot interactively →