KNG1

Across TCGA patient cohorts, KNG1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KNG1-associated genes across cancer lineages are Notch1, TIGAR, and TFRC. Each is linked with KNG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KNG1-to-partner and partner-to-KNG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KNG1-low versus KNG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KNG1→partner) and Y-score (partner→KNG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.152	+2.598	.002	.005	3	3
UCEC	TIGAR →	+0.106	+1.689	.049	.007	3	3
LUSC	TFRC →	+0.653	+2.179	.043	.035	3	2
SKCM	DJ-1 →	+0.311	+2.584	<.001	.009	3	2
UCEC	JNK_pT183_Y185 →	-0.153	-2.222	.010	.010	3	2
UCEC	p62 Lck ligand →	+0.475	+3.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by KNG1 expression — UCEC

Explore this box plot interactively →