KNG1

Across TCGA pan-cancer cohorts, KNG1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of KNG1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KNG1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types KNG1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where KNG1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KNG1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.464	<.001	12	view →
LUAD	Female	III,IV	−1.365	<.001	9	view →
COAD	Male	All	−1.010	<.001	9	view →
LSCC	Male	All	−1.230	<.001	8	view →
PDAC	Female	All	+0.626	<.001	5	view →
OV	All	All	−0.822	.019	2	view →
CCRCC	Male	III,IV	−0.278	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

KNG1–HNSC

Open the HNSC breakdown →