homer scaffold protein 1Genealiases: HOMER · HOMER1A · HOMER1B · HOMER1C · SYN47 · Ves-1
Q-omics provides the consensus-scored HOMER1 profile across patient tissues and cancer cell-line models. HOMER1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, HOMER1 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, HOMER1 RNA expression shows 19,415 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LIHC, KIRC, and UVM as cancer lineages where HOMER1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HOMER1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HOMER1 survival associations across molecular data types. HOMER1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (3) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HOMER1 RNA expression–survival associations across cancer types. High HOMER1 expression shows unfavorable associations in LIHC, UVM, ACC, BLCA, PAAD and MESO. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for HOMER1 RNA expression.
This table summarizes HOMER1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for HOMER1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HOMER1 shows lower tumor expression in KIRC, KICH and THCA and higher tumor expression in HNSC, COAD and LIHC. The KIRC box plot shows higher HOMER1 RNA expression in normal versus tumor tissue (log2 FC = −1.904, t-test p < 0.001).
This table shows molecular features associated with HOMER1 in patient tissues and cancer cell lines. In patient samples, HOMER1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, HOMER1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Myeloma, while CRISPR and shRNA rows add functional-dependency signals in OVARY and LARGE_INTESTINE.
