HOMER1

Across TCGA pan-cancer cohorts, HOMER1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HOMER1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HOMER1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HOMER1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where HOMER1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.246	0.797	.001	22	view →
CCRCC	DFS	Tertile	IV	0.156	0.908	.024	17	view →
PDAC	OS	Median	All	0.797	0.892	.017	12	view →
GBM	DFS	Quartile	All	0.840	0.632	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HOMER1–LUAD (DFS)

Open the LUAD breakdown →