HOMER1

Across TCGA pan-cancer cohorts, HOMER1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of HOMER1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HOMER1 RNA is repressed in tumor relative to normal tissue. In most cancer types HOMER1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where HOMER1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HOMER1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.904	<.001	12	view →
HNSC	All	IV	+0.701	<.001	12	view →
KICH	Female	II,III,IV	−2.762	<.001	10	view →
COAD	Female	II,III,IV	+1.518	<.001	10	view →
THCA	All	II,III,IV	−0.854	<.001	8	view →
LIHC	All	II,III,IV	+0.740	<.001	8	view →
BLCA	Male	III,IV	+1.454	<.001	6	view →
STAD	All	II,III,IV	+0.653	.005	6	view →
LUAD	Female	II,III,IV	−0.698	<.001	5	view →
CHOL	Male	All	+1.573	<.001	4	view →
UCEC	All	II,III,IV	+0.888	.021	4	view →
READ	All	III,IV	+2.120	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

HOMER1–KIRC

Open the KIRC breakdown →