HOMER1

Across TCGA pan-cancer cohorts, HOMER1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated HOMER1 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher HOMER1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HOMER1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and READ show a favorable association.

LIHC, UVM, and ACC are the cancer types where HOMER1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Quartile	II,III,IV	0.380	0.714	<.001	94	view →
UVM	DFS	Tertile	II,III,IV	0.319	0.824	<.001	77	view →
ACC	OS	Quartile	All	0.722	0.971	.003	30	view →
BLCA	OS	Median	III,IV	0.271	0.459	<.001	28	view →
PAAD	OS	Quartile	All	0.170	0.514	.001	28	view →
MESO	OS	Median	IV	0.344	0.811	.004	27	view →
DLBC	DFS	Tertile	All	0.413	1.000	.012	27	view →
SARC	OS	Tertile	All	0.667	0.834	.003	24	view →
SKCM	OS	Quartile	III,IV	0.882	0.730	.003	22	view →
STAD	DFS	Quartile	All	0.489	0.663	.012	21	view →
KIRP	OS	Median	IV	0.045	0.523	.024	18	view →
READ	DFS	Tertile	III,IV	0.981	0.622	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

HOMER1–LIHC (OS)

Open the LIHC breakdown →