HOMER1

Across TCGA cell cohorts, HOMER1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOMER1-associated genes across cancer lineages are ADAM7, KRTAP19-8, and CCL18. Each is linked with HOMER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOMER1-to-partner and partner-to-HOMER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by HOMER1-low versus HOMER1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMER1→partner) and Y-score (partner→HOMER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAM7 →	+0.021	+4.922	.001	.009	3	2
OVARY	KRTAP19-8 →	+0.410	+5.807	<.001	.001	3	1
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ADAM7 by HOMER1 expression — BLOOD_Leukemia

Explore this box plot interactively →