HOMER1

Across TCGA patient cohorts, HOMER1 protein abundance is significantly associated with the protein abundance of many other proteins, with 18,123 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HOMER1-associated proteins across cancer lineages are DNAJC1, ATP2A3, and SH3KBP1_S183. Each is linked with HOMER1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HOMER1-to-partner and partner-to-HOMER1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOMER1 versus DNAJC1 in BRCA, with a Pearson correlation of -0.40.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMER1→partner) and Y-score (partner→HOMER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNAJC1 →	-0.570	-0.481	<.001	<.001	3	5
BRCA	ATP2A3 →	-0.727	-0.480	.001	<.001	3	5
LSCC	SH3KBP1_S183 →	-0.700	-0.328	<.001	<.001	3	5
GBM	HCLS1 →	-0.451	-0.414	<.001	<.001	3	4
GBM	RRBP1 →	-0.406	-0.661	.001	<.001	2	5
GBM	CTSS →	-0.491	-0.451	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,123 associations by consensus.

HOMER1 vs DNAJC1 — BRCA

Explore this scatter interactively →