F-box and WD repeat domain containing 11Genealiases: BTRC2 · BTRCP2 · FBW1B · FBXW1B · Fbw11 · Hos
Q-omics provides the consensus-scored FBXW11 profile across patient tissues and cancer cell-line models. FBXW11 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, FBXW11 is differentially expressed in 8, with the highest sampling consensus in LIHC. Additionally, FBXW11 protein abundance shows 28,589 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight KIRC, LIHC, and LUAD as cancer lineages where FBXW11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FBXW11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FBXW11 survival associations across molecular data types. FBXW11 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FBXW11 RNA expression–survival associations across cancer types. High FBXW11 expression shows unfavorable associations in STAD, CESC and LIHC, but favorable associations in KIRC, MESO and LGG. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for FBXW11 RNA expression.
This table summarizes FBXW11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 9. The strongest signals are observed in LIHC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for FBXW11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FBXW11 shows lower tumor expression in LUSC, THCA and UCEC and higher tumor expression in LIHC, CHOL and READ. The LIHC box plot shows higher FBXW11 RNA expression in tumor versus normal tissue (log2 FC = +1.122, t-test p < 0.001).
This table shows molecular features associated with FBXW11 in patient tissues and cancer cell lines. In patient samples, FBXW11 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, FBXW11 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and LARGE_INTESTINE.
