FBXW11

Across TCGA patient cohorts, FBXW11 mutation is significantly associated with the RNA expression of many other genes, with 6,611 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW11-associated genes across cancer lineages are RPS10-NUDT3, SSRP1, and FADS1. Each is linked with FBXW11 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXW11-to-partner and partner-to-FBXW11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS10-NUDT3 grouped by FBXW11-low versus FBXW11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW11→partner) and Y-score (partner→FBXW11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS10-NUDT3 →	+0.190	+1.736	<.001	<.001	3	3
UCEC	SSRP1 →	+0.536	+1.758	<.001	<.001	3	2
UCEC	FADS1 →	+0.700	+1.536	<.001	.002	3	2
UCEC	ALDOA →	+0.450	+1.954	<.001	<.001	3	2
UCEC	CCT5 →	+0.578	+1.964	<.001	<.001	3	2
UCEC	BAG3 →	+0.619	+2.192	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,611 associations by consensus.

RPS10-NUDT3 by FBXW11 expression — UCEC

Explore this box plot interactively →