FBXW11

Across TCGA pan-cancer cohorts, FBXW11 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FBXW11’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where FBXW11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FBXW11 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LIHC, LUSC, and CHOL are the cancer types where FBXW11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	III,IV	+1.122	<.001	9	view →
LUSC	All	All	−0.311	<.001	4	view →
CHOL	All	All	+1.961	<.001	3	view →
THCA	All	All	−0.276	.008	3	view →
UCEC	All	All	−0.967	<.001	2	view →
READ	All	III,IV	+0.455	.021	2	view →
KICH	All	All	−0.501	.020	1	view →
KIRP	Male	All	−0.397	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FBXW11–LIHC

Open the LIHC breakdown →