FBXW11

Across TCGA patient cohorts, FBXW11 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXW11-associated genes across cancer lineages are Caspase-7-cleavedD198, FASN, and FoxM1. Each is linked with FBXW11 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXW11-to-partner and partner-to-FBXW11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FBXW11-low versus FBXW11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW11→partner) and Y-score (partner→FBXW11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.462	+3.008	<.001	.019	3	3
UCEC	FASN →	+0.386	+1.530	.001	.004	3	2
UCEC	FoxM1 →	+0.251	+1.999	.001	<.001	3	2
UCEC	Ku80 →	+0.299	+2.013	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.152	-2.986	<.001	<.001	3	2
UCEC	p70-S6K →	+0.122	+1.557	.035	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by FBXW11 expression — COAD

Explore this box plot interactively →