FBXW11

Across TCGA cell cohorts, FBXW11 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXW11-associated genes across cancer lineages are AVP, PAX1, and TACR3. Each is linked with FBXW11 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXW11-to-partner and partner-to-FBXW11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by FBXW11-low versus FBXW11-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXW11→partner) and Y-score (partner→FBXW11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Leukemia	PAX1 →	+0.053	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TACR3 →	+0.038	+5.060	<.001	.001	3	1
BLOOD_Leukemia	OR1L3 →	+0.057	+4.276	.008	.007	3	1
BLOOD_Leukemia	PRND →	+0.006	+4.874	.001	.002	3	1
BLOOD_Leukemia	NKX2-6 →	+0.544	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AVP by FBXW11 expression — BLOOD_Lymphoma

Explore this box plot interactively →