FBXW11

Across TCGA pan-cancer cohorts, FBXW11 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FBXW11’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where FBXW11 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FBXW11 is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, CCRCC, and PDAC are the cancer types where FBXW11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXW11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−0.161	<.001	6	view →
CCRCC	All	II,III,IV	+0.158	.014	2	view →
PDAC	Male	III,IV	−0.905	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

FBXW11–LSCC

Open the LSCC breakdown →