Q-omics provides the consensus-scored DENND11 profile across patient tissues and cancer cell-line models. DENND11 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, DENND11 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, DENND11 RNA expression shows 20,956 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, THCA, and UVM as cancer lineages where DENND11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DENND11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DENND11 survival associations across molecular data types. DENND11 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (4) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DENND11 RNA expression–survival associations across cancer types. High DENND11 expression shows unfavorable associations in CESC and MESO, but favorable associations in KIRC, HNSC, SKCM and LAML. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for DENND11 RNA expression.
This table summarizes DENND11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 3. The strongest signals are observed in THCA for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for DENND11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DENND11 shows lower tumor expression in THCA, KICH and KIRP and higher tumor expression in COAD, LIHC and UCEC. The THCA box plot shows higher DENND11 RNA expression in normal versus tumor tissue (log2 FC = −1.024, t-test p < 0.001).
This table shows molecular features associated with DENND11 in patient tissues and cancer cell lines. In patient samples, DENND11 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, DENND11 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
