DENND11

Across TCGA patient cohorts, DENND11 protein abundance is significantly associated with the RNA expression of many other genes, with 6,476 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DENND11-associated genes across cancer lineages are CCDC80, ANK2, and PAPLN. Each is linked with DENND11 in more than 3 cancer types. Because this analysis shows association rather than direction, both DENND11-to-partner and partner-to-DENND11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND11 versus CCDC80 in BRCA, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND11→partner) and Y-score (partner→DENND11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCDC80 →	-1.177	-0.352	<.001	<.001	3	4
OV	ANK2 →	-1.574	-0.689	.006	.001	3	3
UCEC	PAPLN →	-0.767	-0.334	.001	.001	3	3
UCEC	SRPX →	-0.972	-0.345	<.001	<.001	3	3
PDAC	CLIP3 →	-0.658	-0.508	<.001	.004	3	3
UCEC	CNRIP1 →	-0.716	-0.266	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,476 associations by consensus.

DENND11 vs CCDC80 — BRCA

Explore this scatter interactively →