DENND11

Across TCGA pan-cancer cohorts, DENND11 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DENND11’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DENND11 RNA is repressed in tumor relative to normal tissue. In most cancer types DENND11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where DENND11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.024	<.001	9	view →
KICH	Male	All	−0.962	<.001	8	view →
COAD	Male	All	+0.687	<.001	6	view →
KIRP	Male	All	−0.617	<.001	6	view →
LIHC	Female	All	+0.891	<.001	5	view →
UCEC	All	III,IV	+0.964	.016	4	view →
STAD	All	II,III,IV	+0.468	.023	4	view →
CHOL	All	All	+1.198	.003	2	view →
PRAD	All	All	+0.540	<.001	2	view →
KIRC	All	All	+0.390	.002	2	view →
LUAD	Female	II,III,IV	−0.629	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DENND11–THCA

Open the THCA breakdown →