DENND11

Across TCGA pan-cancer cohorts, DENND11 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DENND11 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DENND11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DENND11 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, HNSC, and SKCM are the cancer types where DENND11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.754	0.532	<.001	147	view →
HNSC	OS	Median	All	0.832	0.699	<.001	95	view →
SKCM	DFS	Median	All	0.674	0.558	<.001	45	view →
CESC	DFS	Median	All	0.765	0.881	<.001	42	view →
MESO	DFS	Median	II,III,IV	0.290	0.611	.006	36	view →
LUAD	OS	Quartile	III,IV	0.726	0.329	.002	34	view →
LAML	DFS	Quartile	All	0.557	0.264	.002	34	view →
LGG	DFS	Tertile	All	0.511	0.322	<.001	33	view →
OV	DFS	Median	All	0.420	0.341	.009	30	view →
READ	OS	Median	II,III,IV	0.927	0.407	.021	17	view →
THCA	OS	Quartile	II,III,IV	0.563	0.863	.007	16	view →
LUSC	DFS	Quartile	III,IV	0.133	0.774	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DENND11–KIRC (OS)

Open the KIRC breakdown →