DENND11

Across TCGA patient cohorts, DENND11 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND11-associated genes across cancer lineages are eIF4G, JNK2, and Ku80. Each is linked with DENND11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND11-to-partner and partner-to-DENND11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by DENND11-low versus DENND11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND11→partner) and Y-score (partner→DENND11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.293	+3.169	.022	.018	3	1
UCEC	JNK2 →	+0.263	+1.884	.001	.030	3	1
UCEC	Ku80 →	+0.368	+3.013	<.001	<.001	3	1
UCEC	MEK1 →	+0.513	+4.087	<.001	<.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.491	-2.459	.008	.019	3	1
UCEC	p62 Lck ligand →	+0.303	+2.331	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4G by DENND11 expression — UCEC

Explore this box plot interactively →