DENND11

Across TCGA pan-cancer cohorts, DENND11 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DENND11’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where DENND11 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DENND11 is over-expressed in tumor.

CCRCC, PDAC, and LUAD are the cancer types where DENND11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.186	<.001	4	view →
PDAC	All	IV	+0.415	.044	2	view →
LUAD	Female	III,IV	+0.238	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

DENND11–CCRCC

Open the CCRCC breakdown →