DENND11

Across TCGA patient cohorts, DENND11 mutation is significantly associated with the RNA expression of many other genes, with 4,923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND11-associated genes across cancer lineages are KRTAP22-1, RBMY2JP, and RNU4-7P. Each is linked with DENND11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND11-to-partner and partner-to-DENND11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP22-1 grouped by DENND11-low versus DENND11-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND11→partner) and Y-score (partner→DENND11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KRTAP22-1 →	+0.093	+8.471	<.001	.005	3	2
BRCA	RBMY2JP →	+0.029	+8.471	<.001	.005	3	2
COAD	RNU4-7P →	+1.349	+4.807	<.001	.004	3	2
COAD	RN7SL756P →	+0.748	+4.037	<.001	.004	3	2
SKCM	HSBP1P1 →	+0.240	+4.500	.003	.005	3	2
SKCM	YWHAZP1 →	+0.046	+4.867	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,923 associations by consensus.

KRTAP22-1 by DENND11 expression — BRCA

Explore this box plot interactively →