DENND11

Across TCGA cell cohorts, DENND11 RNA expression is significantly associated with the RNA expression of many other genes, with 12,000 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DENND11-associated genes across cancer lineages are ZNF862, MKRN1, and KMT2C. Each is linked with DENND11 in more than 15 cancer types. Because this analysis shows association rather than direction, both DENND11-to-partner and partner-to-DENND11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND11 versus ZNF862 in LARGE_INTESTINE, with a Pearson correlation of 0.49.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND11→partner) and Y-score (partner→DENND11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF862 →	+1.187	+1.091	<.001	<.001	3	15
BLOOD_Myeloma	MKRN1 →	+1.171	+1.198	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	KMT2C →	+1.087	+1.288	<.001	<.001	3	15
STOMACH	ZKSCAN1 →	+1.097	+0.955	<.001	.002	2	15
OESOPHAGUS	UBN2 →	+0.871	+1.219	<.001	.001	1	16
PANCREAS	ZNF212 →	+0.918	+1.140	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,000 associations by consensus.

DENND11 vs ZNF862 — LARGE_INTESTINE

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