DENND11

Across TCGA cell cohorts, DENND11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,888 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DENND11-associated GO terms across cancer lineages are Positive regulation of cytoplasmic mRNA processing body assembly, Positive regulation of organelle assembly, and Regulation of mRNA stability. Each is linked with DENND11 in more than 12 cancer types. Because this analysis shows association rather than direction, both DENND11-to-partner and partner-to-DENND11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic mRNA processing body assembly grouped by DENND11-low versus DENND11-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND11→partner) and Y-score (partner→DENND11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of cytoplasmic mRNA processing body assembly →	+0.121	+1.154	.002	.002	3	13
LARGE_INTESTINE	Positive regulation of organelle assembly →	+0.064	+0.781	<.001	.004	3	13
OVARY	Regulation of mRNA stability →	+0.057	+1.258	<.001	<.001	3	12
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.094	+0.881	<.001	<.001	3	12
BONE	Regulation of mRNA catabolic process →	+0.057	+0.958	.004	.008	3	12
OVARY	Regulation of myoblast fusion →	+0.096	+0.921	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,888 associations by consensus.

Positive regulation of cytoplasmic mRNA processing body assembly by DENND11 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →