cytochrome P450 family 27 subfamily A member 1Genealiases: CP27 · CTX · CYP27
Q-omics provides the consensus-scored CYP27A1 profile across patient tissues and cancer cell-line models. CYP27A1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, CYP27A1 is differentially expressed in 13, with the highest sampling consensus in LUAD. Additionally, CYP27A1 protein abundance shows 18,872 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, LUAD, and LSCC as cancer lineages where CYP27A1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CYP27A1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CYP27A1 survival associations across molecular data types. CYP27A1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (3) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CYP27A1 RNA expression–survival associations across cancer types. High CYP27A1 expression shows favorable associations in HNSC, KIRC, ACC, DLBC, KIRP and BRCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for CYP27A1 RNA expression.
This table summarizes CYP27A1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 7. The strongest signals are observed in LUAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for CYP27A1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CYP27A1 shows lower tumor expression in LUAD, LUSC, KICH, UCEC and BLCA and higher tumor expression in KIRC. The LUAD box plot shows higher CYP27A1 RNA expression in normal versus tumor tissue (log2 FC = −2.143, t-test p < 0.001).
This table shows molecular features associated with CYP27A1 in patient tissues and cancer cell lines. In patient samples, CYP27A1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, CYP27A1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SKIN.
