CYP27A1

Across TCGA pan-cancer cohorts, CYP27A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CYP27A1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CYP27A1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP27A1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, KIRC, and LUSC are the cancer types where CYP27A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP27A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−2.143	<.001	11	view →
KIRC	All	II,III,IV	+0.791	<.001	10	view →
LUSC	Male	All	−2.671	<.001	8	view →
KICH	All	II,III,IV	−2.185	<.001	8	view →
UCEC	All	II,III,IV	−1.670	<.001	8	view →
BLCA	Male	All	−2.265	<.001	6	view →
HNSC	All	All	−1.080	<.001	6	view →
CHOL	All	All	−3.673	<.001	5	view →
COAD	All	All	−0.713	.002	5	view →
BRCA	All	II,III,IV	−0.423	.003	4	view →
PRAD	All	All	−1.488	<.001	2	view →
LIHC	Female	All	−1.442	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CYP27A1–LUAD

Open the LUAD breakdown →