CYP27A1

Across TCGA patient cohorts, CYP27A1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,174 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYP27A1-associated genes across cancer lineages are ARL11, CHIT1, and DNAJC5B. Each is linked with CYP27A1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CYP27A1-to-partner and partner-to-CYP27A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP27A1 versus ARL11 in COAD, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27A1→partner) and Y-score (partner→CYP27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ARL11 →	+0.816	+0.491	<.001	.001	3	8
HNSC	CHIT1 →	+1.320	+0.488	<.001	<.001	3	7
LSCC	DNAJC5B →	+0.658	+0.536	<.001	<.001	3	7
CCRCC	HTRA4 →	+0.738	+0.297	.003	.003	2	8
GBM	FTL →	+0.757	+0.408	<.001	<.001	3	7
LSCC	HS3ST2 →	+1.116	+0.510	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,174 associations by consensus.

CYP27A1 vs ARL11 — COAD

Explore this scatter interactively →