CYP27A1

Across TCGA cell cohorts, CYP27A1 RNA expression is significantly associated with the RNA expression of many other genes, with 9,035 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP27A1-associated genes across cancer lineages are ADPRH, MFGE8, and RASSF4. Each is linked with CYP27A1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CYP27A1-to-partner and partner-to-CYP27A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP27A1 versus ADPRH in SKIN, with a Pearson correlation of 0.61.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27A1→partner) and Y-score (partner→CYP27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADPRH →	+1.610	+3.203	<.001	<.001	3	7
BONE	MFGE8 →	+2.113	+1.700	.001	.001	3	7
BLOOD_Leukemia	RASSF4 →	+1.801	+0.774	.001	.003	2	8
SOFT_TISSUE	STAT5A →	+1.637	+1.354	<.001	<.001	3	7
URINARY_TRACT	LRMDA →	+2.287	+1.867	.007	.001	2	7
LUNG_NSCLC_LUSC	SMIM10 →	+2.323	+2.332	.008	.003	1	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,035 associations by consensus.

CYP27A1 vs ADPRH — SKIN

Explore this scatter interactively →