signal transducer and activator of transcription 5AGenealiases: MGF · STAT5
Q-omics provides the consensus-scored STAT5A profile across patient tissues and cancer cell-line models. STAT5A expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, STAT5A is differentially expressed in 14, with the highest sampling consensus in BLCA. Additionally, STAT5A protein abundance shows 27,911 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, BLCA, and LSCC as cancer lineages where STAT5A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for STAT5A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes STAT5A survival associations across molecular data types. STAT5A RNA expression shows survival associations in the most cancer types (25), followed by mutation status (2) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible STAT5A RNA expression–survival associations across cancer types. High STAT5A expression shows unfavorable associations in LGG and OV, but favorable associations in HNSC, MESO, LUAD and CESC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify HNSC as the clearest survival context for STAT5A RNA expression.
This table summarizes STAT5A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 7. The strongest signals are observed in LUSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for STAT5A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. STAT5A shows lower tumor expression in BLCA, LUSC, LUAD and UCEC and higher tumor expression in LIHC and THCA. The BLCA box plot shows higher STAT5A RNA expression in normal versus tumor tissue (log2 FC = −1.322, t-test p < 0.001).
This table shows molecular features associated with STAT5A in patient tissues and cancer cell lines. In patient samples, STAT5A shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, STAT5A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and BONE.
