STAT5A

Across TCGA pan-cancer cohorts, STAT5A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated STAT5A data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher STAT5A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated STAT5A expression acts as an unfavorable survival marker.

THCA and UCEC are the cancer types where STAT5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.049	0.828	<.001	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

STAT5A–THCA (DFS)

Open the THCA breakdown →