STAT5A

Across TCGA pan-cancer cohorts, STAT5A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of STAT5A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where STAT5A RNA is repressed in tumor relative to normal tissue. In most cancer types STAT5A is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, LIHC, and LUSC are the cancer types where STAT5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAT5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.322	<.001	8	view →
LIHC	Female	II,III,IV	+1.165	<.001	8	view →
LUSC	Male	II,III,IV	−1.080	<.001	8	view →
LUAD	Female	III,IV	−0.774	<.001	8	view →
THCA	All	II,III,IV	+0.360	<.001	7	view →
UCEC	All	II,III,IV	−1.803	<.001	6	view →
BRCA	All	III,IV	−1.666	<.001	6	view →
KICH	Female	All	−0.943	<.001	6	view →
CHOL	All	All	+1.901	<.001	5	view →
STAD	All	II,III,IV	+0.827	.001	5	view →
KIRC	Male	All	+0.339	<.001	5	view →
ESCA	All	All	+1.316	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

STAT5A–BLCA

Open the BLCA breakdown →