STAT5A

Across TCGA pan-cancer cohorts, STAT5A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated STAT5A data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher STAT5A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated STAT5A expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where STAT5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.846	0.470	<.001	25	view →
PDAC	DFS	Tertile	All	0.902	0.654	.003	16	view →
HNSC	DFS	Tertile	All	0.929	1.000	.021	5	view →
CCRCC	OS	Median	II,III,IV	1.000	0.499	.025	3	view →
GBM	OS	Quartile	All	0.395	0.621	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

STAT5A–LUAD (DFS)

Open the LUAD breakdown →