STAT5A

Across TCGA cell cohorts, STAT5A mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAT5A-associated genes across cancer lineages are IL5, MSTN, and VWC2L. Each is linked with STAT5A in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT5A-to-partner and partner-to-STAT5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL5 grouped by STAT5A-low versus STAT5A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT5A→partner) and Y-score (partner→STAT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL5 →	+0.292	+3.853	<.001	.002	3	2
BLOOD_Leukemia	MSTN →	+0.349	+3.383	<.001	.007	3	2
BLOOD_Leukemia	VWC2L →	+0.009	+3.661	<.001	.001	3	2
BLOOD_Leukemia	ELOA3CP →	+0.121	+3.526	<.001	.008	3	2
LARGE_INTESTINE	CPLX4 →	+0.022	+3.807	.002	.001	3	2
LARGE_INTESTINE	F11 →	+0.049	+3.297	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

IL5 by STAT5A expression — BLOOD_Leukemia

Explore this box plot interactively →