STAT5A

Across TCGA cell cohorts, STAT5A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,528 significant associations in total. BONE shows the largest number of these associations.

The most reproducible STAT5A-associated GO terms across cancer lineages are Regulation of tolerance induction dependent upon immune response, Regulation of viral process, and Vacuolar transport. Each is linked with STAT5A in more than 14 cancer types. Because this analysis shows association rather than direction, both STAT5A-to-partner and partner-to-STAT5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tolerance induction dependent upon immune response grouped by STAT5A-low versus STAT5A-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT5A→partner) and Y-score (partner→STAT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of tolerance induction dependent upon immune response →	+1.618	+1.653	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.094	+0.932	<.001	.002	3	14
LUNG_SCLC	Vacuolar transport →	+0.055	+1.353	.003	.004	3	12
BONE	Endocytic recycling →	+0.091	+1.662	<.001	<.001	3	12
BREAST	Regulation of intracellular protein transport →	+0.083	+1.748	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of tumor necrosis factor production →	+0.103	+1.743	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,528 associations by consensus.

Regulation of tolerance induction dependent upon immune response by STAT5A expression — KIDNEY

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