STAT5A

Across TCGA patient cohorts, STAT5A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT5A-associated genes across cancer lineages are PKC-delta_pS664, ATM, and GATA6. Each is linked with STAT5A in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT5A-to-partner and partner-to-STAT5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by STAT5A-low versus STAT5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT5A→partner) and Y-score (partner→STAT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.145	-3.160	.009	.019	3	2
UCEC	ATM →	-0.715	-3.308	<.001	.009	3	2
UCEC	GATA6 →	-0.161	-3.000	.025	.035	3	1
UCEC	JNK2 →	+0.295	+3.026	.001	.018	3	1
UCEC	MEK1 →	+0.486	+2.584	.004	.011	3	1
UCEC	MSH6 →	-0.379	-2.990	.013	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PKC-delta_pS664 by STAT5A expression — UCEC

Explore this box plot interactively →