CYP27A1

Across TCGA patient cohorts, CYP27A1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP27A1-associated genes across cancer lineages are Di-Ras3, EGFR_pY1068, and JNK2. Each is linked with CYP27A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27A1-to-partner and partner-to-CYP27A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by CYP27A1-low versus CYP27A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27A1→partner) and Y-score (partner→CYP27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.121	-2.986	.043	.035	3	2
UCEC	EGFR_pY1068 →	-0.253	-2.321	.012	.034	3	1
UCEC	JNK2 →	+0.218	+1.710	.006	.025	3	1
UCEC	p62 Lck ligand →	+0.336	+3.169	.010	.018	3	1
UCEC	p90 RSK →	+0.252	+2.125	.001	.010	3	1
UCEC	Annexin-1 →	+0.584	+1.894	.005	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Di-Ras3 by CYP27A1 expression — UCEC

Explore this box plot interactively →