CYP27A1

Across TCGA pan-cancer cohorts, CYP27A1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CYP27A1 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher CYP27A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CYP27A1 expression acts as an unfavorable survival marker.

STAD, SARC, and UCEC are the cancer types where CYP27A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.183	0.660	.009	12	view →
SARC	OS	Median	All	0.238	0.826	.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CYP27A1–STAD (OS)

Open the STAD breakdown →