CYP27A1

Across TCGA cell cohorts, CYP27A1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP27A1-associated genes across cancer lineages are ASPN, C6orf118, and DEFA4. Each is linked with CYP27A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27A1-to-partner and partner-to-CYP27A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by CYP27A1-low versus CYP27A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27A1→partner) and Y-score (partner→CYP27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.054	+3.426	<.001	.007	3	1
LARGE_INTESTINE	C6orf118 →	+0.154	+3.115	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PRR23B →	+0.003	+3.217	<.001	.006	3	1
OVARY	FEZF2 →	+0.011	+3.990	.001	.003	3	1
OVARY	OR5AN1 →	+0.010	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ASPN by CYP27A1 expression — LARGE_INTESTINE

Explore this box plot interactively →