CYP27A1

Across TCGA cell cohorts, CYP27A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,447 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP27A1-associated GO terms across cancer lineages are Cholesterol catabolic process, Sterol catabolic process, and Protein polyubiquitination. Each is linked with CYP27A1 in more than 10 cancer types. Because this analysis shows association rather than direction, both CYP27A1-to-partner and partner-to-CYP27A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cholesterol catabolic process grouped by CYP27A1-low versus CYP27A1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27A1→partner) and Y-score (partner→CYP27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cholesterol catabolic process →	-0.362	-2.008	<.001	<.001	3	11
BREAST	Sterol catabolic process →	-0.362	-2.008	<.001	<.001	3	11
LUNG_SCLC	Protein polyubiquitination →	+0.034	+1.728	<.001	<.001	3	9
CNS	Autophagy of mitochondrion →	+0.056	+1.704	.001	.001	3	9
LUNG_SCLC	Nuclear envelope organization →	+0.067	+1.371	<.001	<.001	3	9
URINARY_TRACT	Positive regulation of protein transport →	+0.067	+1.518	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,447 associations by consensus.

Cholesterol catabolic process by CYP27A1 expression — BREAST

Explore this box plot interactively →