CYP27A1

Across TCGA patient cohorts, CYP27A1 mutation is significantly associated with the RNA expression of many other genes, with 2,802 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP27A1-associated genes across cancer lineages are RNA5SP85, RNU6-796P, and SNORD66. Each is linked with CYP27A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP27A1-to-partner and partner-to-CYP27A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP85 grouped by CYP27A1-low versus CYP27A1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP27A1→partner) and Y-score (partner→CYP27A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP85 →	+0.189	+4.578	<.001	.005	3	2
LUAD	RNU6-796P →	+0.502	+4.076	<.001	.004	3	2
SKCM	SNORD66 →	+0.574	+5.368	<.001	<.001	3	2
BLCA	MIR6871 →	+0.710	+4.216	.001	.003	3	2
LUAD	DBIP2 →	+0.394	+3.981	<.001	.006	3	2
UCEC	RNA5SP386 →	+0.246	+2.350	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,802 associations by consensus.

RNA5SP85 by CYP27A1 expression — LUSC

Explore this box plot interactively →