ATP binding cassette subfamily C member 10Genealiases: EST182763 · MRP7 · SIMRP7
Q-omics provides the consensus-scored ABCC10 profile across patient tissues and cancer cell-line models. ABCC10 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, ABCC10 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, ABCC10 RNA expression shows 20,633 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight MESO, HNSC, and ACC as cancer lineages where ABCC10 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ABCC10 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ABCC10 survival associations across molecular data types. ABCC10 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (6) and mass-spec protein abundance (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ABCC10 RNA expression–survival associations across cancer types. High ABCC10 expression shows unfavorable associations in MESO, KIRC, ACC, LGG, LIHC and SKCM. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for ABCC10 RNA expression.
This table summarizes ABCC10 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 10. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for ABCC10. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ABCC10 shows lower tumor expression in KICH and higher tumor expression in HNSC, COAD, LIHC, LUAD and STAD. The HNSC box plot shows higher ABCC10 RNA expression in tumor versus normal tissue (log2 FC = +0.895, t-test p < 0.001).
This table shows molecular features associated with ABCC10 in patient tissues and cancer cell lines. In patient samples, ABCC10 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ABCC10 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BLOOD_Leukemia.
