ABCC10

Across TCGA patient cohorts, ABCC10 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC10-associated genes across cancer lineages are ATM, GAPDH, and MEK1. Each is linked with ABCC10 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCC10-to-partner and partner-to-ABCC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ABCC10-low versus ABCC10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC10→partner) and Y-score (partner→ABCC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.669	-3.000	<.001	.035	3	4
COAD	GAPDH →	+0.576	+3.008	.028	.019	3	3
UCEC	MEK1 →	+0.254	+1.263	.023	.019	3	2
UCEC	MSH6 →	-0.313	-1.584	.001	.015	3	2
UCEC	PCNA →	+0.193	+1.765	.003	.011	3	2
UCEC	TFRC →	+0.339	+2.459	.037	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by ABCC10 expression — COAD

Explore this box plot interactively →