ATP binding cassette subfamily B member 1Genealiases: ABC20 · CD243 · CLCS · ENPAT · GP170 · MDR1
Q-omics provides the consensus-scored ABCB1 profile across patient tissues and cancer cell-line models. ABCB1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ABCB1 is differentially expressed in 12, with the highest sampling consensus in KIRC. Additionally, ABCB1 protein abundance shows 20,669 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, and GBM as cancer lineages where ABCB1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ABCB1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ABCB1 survival associations across molecular data types. ABCB1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (9) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ABCB1 RNA expression–survival associations across cancer types. High ABCB1 expression shows favorable associations in KIRC, HNSC, SKCM, BRCA, MESO and THCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ABCB1 RNA expression.
This table summarizes ABCB1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for ABCB1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ABCB1 shows lower tumor expression in KIRC, KICH, COAD, LUAD, BLCA and LUSC. The KIRC box plot shows higher ABCB1 RNA expression in normal versus tumor tissue (log2 FC = −2.253, t-test p < 0.001).
This table shows molecular features associated with ABCB1 in patient tissues and cancer cell lines. In patient samples, ABCB1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, ABCB1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
