ABCB1

Across TCGA cell cohorts, ABCB1 mutation is significantly associated with the mutation status of many other genes, with 5,960 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCB1-associated genes across cancer lineages are TRPM3, GLI2, and ATRNL1. Each is linked with ABCB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ABCB1-to-partner and partner-to-ABCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPM3 grouped by ABCB1-low versus ABCB1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB1→partner) and Y-score (partner→ABCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRPM3 →	+3.297	+2.437	.006	.006	1	6
SOFT_TISSUE	GLI2 →	+5.066	+4.502	.007	.007	1	6
LARGE_INTESTINE	ATRNL1 →	+3.216	+2.334	<.001	<.001	1	6
BLOOD_Lymphoma	PLXNA1 →	+3.232	+3.523	.006	.006	1	6
BLOOD_Lymphoma	PRRC2C →	+2.969	+3.874	.001	.001	1	6
OVARY	PLCH2 →	+5.345	+4.632	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,960 associations by consensus.

TRPM3 by ABCB1 expression — LUNG_SCLC

Explore this box plot interactively →