ABCB1

Across TCGA pan-cancer cohorts, ABCB1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ABCB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ABCB1 RNA is repressed in tumor relative to normal tissue. In most cancer types ABCB1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where ABCB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−2.253	<.001	12	view →
KICH	Female	III,IV	−5.590	<.001	11	view →
COAD	Female	II,III,IV	−2.526	<.001	9	view →
LUAD	Male	II,III,IV	−1.746	<.001	9	view →
BLCA	All	All	−1.133	<.001	9	view →
LUSC	Female	All	−1.965	<.001	8	view →
HNSC	Male	All	−0.527	.001	8	view →
UCEC	All	All	−2.599	<.001	6	view →
BRCA	Female	II,III,IV	−1.656	<.001	6	view →
THCA	Male	III,IV	−1.107	.002	6	view →
CHOL	All	II,III,IV	−3.660	.001	3	view →
LIHC	Male	All	+0.698	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ABCB1–KIRC

Open the KIRC breakdown →