ABCB1

Across TCGA cell cohorts, ABCB1 mutation is significantly associated with the RNA expression of many other genes, with 529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCB1-associated genes across cancer lineages are ZNF232, GYPB, and C1orf109. Each is linked with ABCB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCB1-to-partner and partner-to-ABCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF232 grouped by ABCB1-low versus ABCB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB1→partner) and Y-score (partner→ABCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF232 →	+0.910	+3.137	<.001	.007	3	3
LUNG_NSCLC_LUSC	GYPB →	+0.080	+4.643	<.001	.008	3	2
LARGE_INTESTINE	C1orf109 →	+0.594	+3.321	.003	.003	3	2
LARGE_INTESTINE	NLN →	+0.615	+2.949	.001	<.001	3	2
LARGE_INTESTINE	RPA1 →	+0.633	+2.265	<.001	.001	3	2
LARGE_INTESTINE	EIF4A1 →	+0.653	+3.640	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 529 associations by consensus.

ZNF232 by ABCB1 expression — SKIN

Explore this box plot interactively →