ABCB1

Across TCGA patient cohorts, ABCB1 mutation is significantly associated with the RNA expression of many other genes, with 5,919 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB1-associated genes across cancer lineages are MCM4, FCER1A, and MCM10. Each is linked with ABCB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCB1-to-partner and partner-to-ABCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM4 grouped by ABCB1-low versus ABCB1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB1→partner) and Y-score (partner→ABCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MCM4 →	+0.664	+4.016	.003	<.001	3	5
LUAD	FCER1A →	-1.164	-2.991	.001	<.001	3	5
COAD	MCM10 →	+0.576	+2.730	<.001	.003	3	5
UCEC	UBE2T →	+0.418	+1.425	.002	.005	3	5
LUAD	CD1E →	-0.925	-2.356	.001	<.001	3	5
LGG	HMGB3P12 →	+0.120	+4.248	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,919 associations by consensus.

MCM4 by ABCB1 expression — STAD

Explore this box plot interactively →