Q-omics provides the consensus-scored HMGB3P12 profile across patient tissues and cancer cell-line models. HMGB3P12 expression is associated with patient survival in 10 of 34 cancer types, with the highest sampling consensus in COAD. Additionally, HMGB3P12 RNA expression shows 6,164 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight COAD, and STAD as cancer lineages where HMGB3P12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes HMGB3P12 survival associations across molecular data types. HMGB3P12 RNA expression shows survival associations in the most cancer types (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

HMGB3P12 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	10	COAD (126)	view →

This table ranks reproducible HMGB3P12 RNA expression–survival associations across cancer types. High HMGB3P12 expression shows unfavorable associations in COAD, ACC, READ, GBM and SKCM, but favorable associations in OV. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for HMGB3P12 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.146	0.605	<.001	126	view →
ACC	DFS	Tertile	All	0.050	0.675	<.001	87	view →
READ	DFS	Tertile	All	0.082	0.845	<.001	36	view →
GBM	OS	Tertile	All	0.069	0.415	<.001	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
OV	OS	Tertile	II,III,IV	0.881	0.830	.019	18	view →

Pink = unfavorable, green = favorable. all 10 lineages →

HMGB3P12-COAD (OS)

Kaplan–Meier survival curve for HMGB3P12 RNA expression in COAD: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with HMGB3P12 in patient tissues and cancer cell lines. In patient samples, HMGB3P12 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	6,164	STAD (5612)	view →
RNA	5,116	SKCM (1207)	view →